Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review
Published: January 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/43167.13465
Wei Zhu, Shiliang Wang, Shaogang Ma, Liuxue Yang, Yali Qiu
1. Department of Internal Medicine, Caiji Town Hospital, No. 1 Suwang Road, Suqian 223800, Jiangsu Province, China.
2. Department of Internal Medicine, Caiji Town Hospital, No. 1 Suwang Road, Suqian 223800, Jiangsu Province, China.
3. Department of Endocrinology and Metabolism, Suqian First Hospital, No. 120 Suzhi Road, Suqian 223800, Jiangsu Province, China.
4. Department of Endocrinology and Metabolism, the Second Affiliated Hospital of Guilin Medical University, No. 212 Renmin Road, Lingui District, Guilin, Guangxi
Zhuang Autonomous Region, China.
5. Department of Neonatal Screening and Care, Women and Children's Hospital of Suqian, No. 9 Ping'an Road, Suqian 223800, Jiangsu Province, China.
Correspondence
Dr. Shaogang Ma,
Department of Endocrinology and Metabolism, Suqian First Hospital, No. 120 Suzhi Road, Suqian City-223800, Jiangsu Province, China.
E-mail: mashaogang@163.com
Klinefelter Syndrome (KS) remains underdiagnosed due to its complex clinical presentation. Here, the authors present the case of a 48-year-old of KS complicated with Type 2 Diabetes Mellitus (DM), hypothyroidism and cryptorchidism as well as perform a literature review. The patient first visited the hospital for diabetes. Male sexual characteristics were missing, complicated with cryptorchidism. Laboratory and chromosome tests were performed to confirm the diagnosis. The patient demonstrated low testosterone and high gonadotropin levels, with the karyotype of 47, XXY. Thus, for diabetes patients who lack male sexual characteristics, gonadal function and chromosome-related examinations should be performed for analysis and differential diagnosis. Based on existing data, there is a pressing need to generate better evidence for KS early diagnosis and comprehensive treatment.
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